Scientist - Process Development (Downstream)

30000.00 - 40000.00 GBP Annual + GBP30000 - GBP40000/annum
12 Jun 2017
10 Jul 2017
Contract Type
Full Time
Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do - join us and contribute to this exciting journey!

Role Overview:

The appointee will be involved in a range of internal platform development and commercial projects, focusing on establishing process development capabilities for the production of both therapeutic proteins and viral vectors for gene therapy applications. Oxford Genetics has a number of on-going programmes in this area, and multiple government supported grant awards, which the recipient will contribute towards. The Process Development Scientist (Downstream) will work together with Scientist colleagues to specify and implement scalable processes for primary recovery and product purification. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential.

Prior experiencing of using relevant techniques, including TFF, ultracentrfugation and AKTA-based chromatography (Affinity, IEX and SEC) is absolutely required, as is experience in developing and implementing associated process for mammalian production systems. The position will work closely with the Cell Line Development, Upstream Process and Analytical teams, and will report to the Chief Technology Officer.

Key Responsibilities:

• Lead, plan and conduct primary recovery and purification experiments including use of statistical approaches for process design and specification (DOE, QbD)
• To support technology transfer activities for commercial manufacturing
• To work closely with internal and external stakeholders to define project goals and deliverables, in line with planned project objectives
• To keep up to date with the scientific literature and developments in the field
• Set an example to other colleagues, and to train and mentor junior staff
• Perform data analysis, author Standard Operating Procedures and write technical reports
• Support and contribute to protection and assessment of intellectual property
• Promote and suggest implementation of new methods, technologies and processes to ensure best practice
• To ensure established quality standards are strictly adhered to, across all on-going activities


• A Ph.D, DPhil or MSc in Chemical Engineering, Biochemical Engineering, Cell Biology or Biochemistry, along with several years industry experience applicable to the role.
• Extensive knowledge of subject area, and ideally a strong network within academic and industry groups
• An engineering mindset - good ability to utilise statistical approaches (in particular Design of Experiments) to optimize processes and procedures
• Prior experience of using TFF and AKTA systems
• Experience in implementing downstream processes for mammalian systems for both for protein (desirable) and viral vector (essential) production
• Highly developed interpersonal, written and verbal skills, including the ability to give presentations and to speak to groups
• High-level attention to detail
• Ability to work under demanding conditions, and to cope with shifting priorities

Job Type: Permanent
Hours: full time
Salary: GBP30,000 - 40,000 per annum

Applicants must be eligible to work in the UK without sponsorship.
We are an equal opportunities employer and welcome applications from all suitably qualified persons regardless of their race, sex, disability, religion/belief, sexual orientation or age.

Please apply online with your CV and covering letter stating ref no 0135.

Please check your email for confirmation that your application has been received and to follow further instructions if applicable