Senior Microscopist

The Francis Crick Institute
33500.00 GBP Annual + subject to skills and experience
09 Aug 2017
31 Aug 2017
Contract Type
Full Time


The position of Senior Microscopist will work within the Crick Advanced Light Microscopy Science and Technology Platform (CALM STP) to support the imaging needs of scientists at the Francis Crick Institute.

The Senior Microscopist will be a member of the CALM STP and report to the Head of CALM. They will join a team who have an in-depth knowledge of microscopes and who work closely with the CRGs to support their microscopy projects.


Imaging is a cornerstone technology underpinning science at the Crick. Achieving our research goals across diverse areas including developmental biology, neuroscience, and cancer requires imaging a variety of specimens, from tissue culture cells through to tissues, and including developmental model organisms. This includes both live imaging of fluorescent-proteins and imaging of fixed, antibody stained samples. To meet this challenge we now seek a Senior Microscopist to work within the CALM STP to support Crick Research Groups (CRGs) in the investigation of a wide range of exciting scientific questions.


The core responsibility of the Senior Microscopist is to ensure that the microscopes are well maintained, and to train CALM users to set up and use the microscopes correctly. Additionally they will advise on the imaging of both living and fixed specimens, have the chance to develop protocols, and assist with interpretation of experimental data. Within the CALM STP we to support imaging across a range of samples, from 2D to 3D cell culture models through into model organisms including zebrafish, fruit flies, and frog eggs.

Specific objectives include, but not limited to;

  • Provide training and advice on the use confocal and widefield microscopy
  • Assist CRGs with advice on specimen preparation when required
  • Assist with the interpretation, and presentation of microscopy data
  • Ensure that the microscopes are well aligned and maintained at all times
  • Help to develop standard operating protocols for the use of newly purchase systems
  • Communicate effectively with other CALM team members
  • Communicate effectively with facility users for the CRGs


The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.


The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:


  • A degree in a physical or life science
  • Imaging experience using confocal and/or widefield microscopes including alignment and maintenance
  • Ability to trouble shoot microscope problems as they arise, and liaise with engineers
  • Good communications skills and enthusiasm for imaging
  • Patience, humour, and the ability to be authoritative while being pleasant
  • Ability to appropriately convey complex technical information, to both experts and non-experts
  • Ability to work effectively within a team
  • Ability to work independently when required
  • Ability to prioritise work and manage multiple tasks
  • Ability to think creatively and problem-solve


  • Experience with multi-photon or spinning disc confocals, and/or widefield microscopy for live cell imaging
  • Training or teaching experience
  • Background in sample preparation for fluorescence microscopy and/ or tissue culture
  • Knowledge of image analysis programs such as Fiji, Imaris or Volocity
  • An interest in new technologies